Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?
نویسندگان
چکیده
منابع مشابه
Invited Review : Biochemical evaluation of the renin - 2 angiotensin system – the good , bad , and absolute ?
متن کامل
Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?
The renin-angiotensin system (RAS) constitutes a key hormonal system in the physiological regulation of blood pressure through peripheral and central mechanisms. Indeed, dysregulation of the RAS is considered a major factor in the development of cardiovascular pathologies, and pharmacological blockade of this system by the inhibition of angiotensin-converting enzyme (ACE) or antagonism of the a...
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Unilateral ureteral obstruction (UUO) is a clinical scenario that leads to obstructive nephropathy. UUO alters the expression of many mediators in the ipsilateral kidney. Renin-angiotensin system (RAS) is involved in UUO. Angiotensin II (Ang II) and angiotensin 1-7 (Ang 1-7) as the main arms of RAS influence kidney function which may alter by UUO. Ang II via Ang II receptor subtypes I (AT1R) ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2016
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00618.2015